Cancer Risk Autosomal Dominant Treatment Available

Lynch Syndrome

Hereditary colorectal cancer syndrome that increases risk of colorectal, endometrial, and other cancers. Lifetime colorectal cancer risk up to 80%.

Genetic Information

Associated Genes

MLH1 MSH2 MSH6 PMS2 EPCAM

Inheritance Pattern

Autosomal Dominant

Carrier Frequency

1 in 279

Signs and Symptoms
  • Colorectal polyps and cancer
  • Endometrial cancer (females)
  • Ovarian cancer
  • Family history of Lynch-associated cancers
Treatment and Management
Treatment is available for this condition.

Frequent colonoscopies, aspirin prophylaxis, risk-reducing surgery

How Is It Inherited?

This condition follows an autosomal dominant inheritance pattern. This means:

  • Only one copy of the altered gene is needed to cause the condition
  • An affected person has a 50% chance of passing it to each child
  • The condition can appear in every generation of an affected family
Medical Reference

For detailed clinical information, visit the GeneReviews article:

GeneReviews: Lynch Syndrome
Quick Facts
Category Cancer Risk
Inheritance Autosomal Dominant
Gene(s) MLH1, MSH2, MSH6, PMS2, EPCAM
Treatable Yes
Have Questions?

Speak with a board-certified genetic counselor to learn more about this condition and what it means for you.

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Resources
GeneReviews Article OMIM Database ClinVar Variants MedlinePlus Genetics
Disclaimer: This information is for educational purposes only and should not replace professional genetic counseling. If you have questions about genetic test results, please consult with a certified genetic counselor.